Projects

Infections of the lower respiratory tract are common causes for medical appointments and hospitalization of children. Differentiation of viral and bacterial infections of infants and toddlers can be particularly challenging. This often leads to inappropriate antibiotic therapy. Currently, the course of the disease cannot be reliably predicted by microbiological or biomarker analysis. In REMUS, research will focus on a rapid diagnostic test which is not only able to detect the pathogen but also to determine the stage of an infection by integrating molecular pathogen detection and characterization of immune response parameters. The “Institut für Mikrosystemtechnik” (IMTEK) of Albert-Ludwigs-Universität Freiburg will work on sample preparation and integration of different classes of analytes (antigen, antibody and pathogen RNA) in the REMUS assay and thus combine advantages of conventional rapid antigen tests with molecular biological diagnostics. By analyzing the different parameters, the REMUS test can support physicians to estimate the course and outcome of an infection and to select a tailored therapy. The proof-of-concept will be shown for respiratory syncytial virus infections in infants and toddlers.