Uni-Logo
Sie sind hier: Startseite Laboratories Urban, Gerald Projects

Projects

Development of AMP-based plasma nanofilms and their validation by means of a MEMS thermal sensor system

Project description

The widespread use of ever new antibiotics increases the evolutionary pressure set on bacteria. This leads to an increasing development of antibiotics resistance with clinically -in some cases fatal- consequences for patients, especially when the medication is not indication specific or not applied appropriately. In this regard, biofilms are of particular importance: antibacterial substances cannot penetrate the biofilm and consequently do not work effectively unless when using significantly higher concentrations of antibiotics. The project team would like to address this problem from a new standpoint: by inhibiting the attachment of bacteria to interfaces, thus preventing the first step of biofilm formation. A promising substance to minimize bacterial colonization at interfaces is the antimicrobial peptides (AMPs). Their effectiveness in regards to a variety of bacteria, fungi and even viruses is very diverse. The AMPs also work effectively against multi-resistant bacteria and lead to their killing even at very low concentrations. AMPs thus belong to a new class of anti-infectives, which have the potential to substitute antibiotics and avoid the concomitant problems of multiresistance. Today, however, the wide use of AMPs is not possible due to the lack of an immobilization method on the target surfaces. During this joint project, the team will investigate a new method. The AMPs shall be brought to and simultaneously immobilized on the surface by means of a plasma jet. The optimization of the matrix polymer for the attachment of the AMPs with regard to the preservation of their specific structure offers a high research interest as well as a first step towards a broad application of AMP-based antibacterial plasma nanofilms. In this joint project, a strong focus will be set on the oral cavity, an area known for its huge amount of bacteria, its bacterial diversity and its constantly changing microbial composition. A successful evaluation of these coatings in harsh conditions, such as those found in the oral cavity, is a milestone for the human and dental medicine. Areas such as implantology, surgery, but also industrial applications, such as the water supply, would enormously benefit from such a solution. In addition, an individualized test system shall be developed, which allows a precise analysis of the produced antibacterial coatings. The successful development and characterization of the planned antibacterial coatings combined with a high-performance thermal sensor system will be a turning point in the effective use of surface-bonded AMPs, as well as a turning point in the global fight against antibiotics resistance.

Start/End of project

01.07.2019 until 30.06.2022

Project manager

Tobias Wieland; Dr. Michael Bergmann

Contact person

Dr. Michael Bergmann
Phone:+49 (0) 761 / 203 7269

Partners

Prof. Dr. Markus Altenburger, Universitätsklinik Freiburg, Klinik für Zahnerhaltungskunde und Parodontologie

Funding

Deutsche Fördergemeinschaft (DFG)
Benutzerspezifische Werkzeuge